Viral G Protein–Coupled Receptor and Kaposi's Sarcoma

Viral G Protein–Coupled Receptor and Kaposi's Sarcoma

The most recently identified human herpesvirus, Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) or human her-pesvirus 8 (HHV-8), has been found to be a necessary, although perhaps not sufficient, etiologic agent for all forms of KS (1, 2). This virus is also invariably present in a rare subset of malignant lymphomas, primary effusion lympho-mas (PELs), and in a significant percentage of pat...

Kaposis sarcoma in a Nairobi hospital.

BACKGROUND Kaposi's sarcoma (KS) is associated epidemiologically with HIV infection and a number of countries have reported a dramatic increase in the incidence of KS with the advent of AIDS. Although AIDS is prevalent in Kenya, no studies on the impact of AIDS on the pattern of KS has been carried out. OBJECTIVE To determine any changes in the pattern of KS that might have occurred since the...

Viral G Protein–coupled Receptor and Kaposi’s Sarcoma: A Model of Paracrine Neoplasia?

A direct and functional interaction between the trimeric G protein Go and Rab5 in G proteincoupled receptor signaling

Kaposi's Sarcoma-Associated Herpesvirus K7 Induces Viral G Protein-Coupled Receptor Degradation and Reduces Its Tumorigenicity

The Kaposi's sarcoma-associated herpesvirus (KSHV) genome encodes a G protein-coupled receptor (vGPCR). vGPCR is a ligand-independent, constitutively active signaling molecule that promotes cell growth and proliferation; however, it is not clear how vGPCR is negatively regulated. We report here that the KSHV K7 small membrane protein interacts with vGPCR and induces its degradation, thereby dam...